METHOD DEVELOPMENT AND VALIDATION OF AMLODIPINE BESYLATE BY UV-VISIBLE SPECTROPHOTOMETRIC METHOD

Authors

  • K. SUJATHA Asst. Professor, Dept of Pharmaceutical Analysis, Vikas College of Pharmaceutical Sciences, Rayanigudem, Suryapet, Telangana
     Author
  • K.SAHANI , B Pharm IV Year, Vikas College of Pharmaceutical Sciences, Rayanigudem, Suryapet, Telangana
     Author
  • K.ANJALI , B Pharm IV Year, Vikas College of Pharmaceutical Sciences, Rayanigudem, Suryapet, Telangana
     Author
  • K.SRIMAHALAXMI , B Pharm IV Year, Vikas College of Pharmaceutical Sciences, Rayanigudem, Suryapet, Telangana
     Author
  • K.RAVINDER , B Pharm IV Year, Vikas College of Pharmaceutical Sciences, Rayanigudem, Suryapet, Telangana
     Author
  • SK.YASMIN , B Pharm IV Year, Vikas College of Pharmaceutical Sciences, Rayanigudem, Suryapet, Telangana
     Author

DOI:

https://doi.org/10.71366/ijwos03072665696

Keywords:

Amlodipine Besylate, API formulation, Quantitative and Qualitative Analysis

Abstract

Methods were reported for the estimation of n in amlodipine besylate dosage forms. UV spectroscopic study was reported for amlodipine besylate in a single dosage form. So the present study was aimed at the development of a simple, accurate, rapid, and economical UV spectrophotometric assay method for the determination of amlodipine besylate in bulk and tablet formulation. The solvent selected for stock solution preparation was water, and the required concentrations were prepared using the same solvent. The λmax for detection of amlodipine besylate was found to be 360nm. In this method, amlodipine besylate followed linearity in the concentration range of 1, 2, 3, 4, 5, 6, 7, 8, and 9 µg/mL with a regression coefficient (r²) of 0.999. The percent drug content was found to be 101.60057 ± 2.0815391 for amlodipine besylate API formulation. The method was found to be accurate and precise, as indicated by recovery studies, with recoveries close to 100% and RSD less than 2.
Inter-day precision: 0.1368
Intraday precision: 1.135
LOD: 0.387269 µg/mL LOQ:1.1735424µg/mL

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Published

2026-07-28

Issue

IJWOS VOLUME-03 ISSUE-07 JULY 2026

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
K. SUJATHA , “METHOD DEVELOPMENT AND VALIDATION OF AMLODIPINE BESYLATE BY UV-VISIBLE SPECTROPHOTOMETRIC METHOD”, Int. J. Web Multidiscip. Stud. pp. 584-603, 2026-07-28 doi: https://doi.org/10.71366/ijwos03072665696 .